{
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  "Package": "Rsmlx",
  "Type": "Package",
  "Title": "R Speaks 'Monolix'",
  "Version": "2024.1.0",
  "Authors@R": "c(\nperson( \"Chloe\", \"Bracis\", role = c(\"ctb\",\"cre\"), email = \"support@lixoft.com\" ),\nperson( \"Frano\", \"Mihaljevic\", role = c(\"aut\") ),\nperson( \"Marc\", \"Lavielle\", role = c(\"aut\") ),\nperson( \"Jonathan\", \"Chauvin\", role = c(\"ctb\") ),\nperson( \"Clémence\", \"Pinaud\", role = c(\"ctb\")))",
  "Maintainer": "Chloe Bracis <support@lixoft.com>",
  "Description": "Provides methods for model building and model evaluation\nof mixed effects models using 'Monolix'\n<https://monolix.lixoft.com>. 'Monolix' is a software tool for\nnonlinear mixed effects modeling that must have been installed\nin order to use 'Rsmlx'. Among other tasks, 'Rsmlx' provides a\npowerful tool for automatic PK model building, performs\nstatistical tests for model assessment, bootstrap simulation\nand likelihood profiling for computing confidence intervals.\n'Rsmlx' also proposes several automatic covariate search\nmethods for mixed effects models.",
  "URL": "https://monolix.lixoft.com/rsmlx/",
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  "Collate": "mlxConnectors.R bootstrap.R buildmlx.R buildVar.R buildAll.R\nconfintmlx.R correlationModelSelection.R\ncovariateModelSelection.R covariateSearch.R\nerrorModelSelection.R llp.R newConnectors.R setSettings.R\ntestmlx.R zzz.R RsmlxTools.R readDatamlx.R pkbuild.R pkpopini.R\nwhichPKmodel.R",
  "License": "BSD_2_clause + file LICENSE",
  "Copyright": "Inria",
  "NeedsCompilation": "no",
  "Encoding": "UTF-8",
  "LazyData": "true",
  "RoxygenNote": "7.3.1",
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  "Repository": "https://marclavielle.r-universe.dev",
  "Date/Publication": "2024-06-10 13:23:28 UTC",
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    "message": "More changes for CRAN submission (remove links to lixoftConnectors in help)\n",
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    "extra/citation.json",
    "extra/citation.txt",
    "extra/contents.json",
    "extra/manual.pdf",
    "extra/Rsmlx.html",
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  "_realowner": "marclavielle",
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      "date": "2018-06-21"
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      "date": "2018-07-16"
    },
    {
      "version": "2.0.2",
      "date": "2019-04-30"
    },
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      "date": "2021-01-19"
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    "buildAll",
    "buildmlx",
    "buildVar",
    "confintmlx",
    "covariateSearch",
    "getEstimatedCovarianceMatrix",
    "getEstimatedIndividualParameters2",
    "getEstimatedPredictions",
    "getEstimatedResiduals",
    "getSimulatedPredictions",
    "getSimulatedResiduals",
    "initRsmlx",
    "pkbuild",
    "pkpopini",
    "readDatamlx",
    "setSettings",
    "testmlx",
    "whichPKmodel"
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      "name": "resMonolix",
      "title": "Monolix results",
      "object": "RsmlxDemo",
      "class": [
        "list"
      ],
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      "table": false,
      "tojson": true
    },
    {
      "name": "RsmlxDemo1.project",
      "title": "Monolix project for warfarin PK - 1",
      "object": "RsmlxDemo",
      "class": [
        "character"
      ],
      "fields": [],
      "table": false,
      "tojson": true
    },
    {
      "name": "RsmlxDemo2.project",
      "title": "Monolix project for warfarin PK - 2",
      "object": "RsmlxDemo",
      "class": [
        "character"
      ],
      "fields": [],
      "table": false,
      "tojson": true
    },
    {
      "name": "warfarin.data",
      "title": "warfarin PKPD data",
      "object": "RsmlxDemo",
      "class": [
        "data.frame"
      ],
      "fields": [
        "id",
        "time",
        "amt",
        "dv",
        "dvid",
        "wt",
        "sex",
        "age"
      ],
      "rows": 515,
      "table": true,
      "tojson": true
    }
  ],
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    {
      "page": "bootmlx",
      "title": "Bootstrapping - case resampling",
      "topics": [
        "bootmlx"
      ]
    },
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      "page": "buildAll",
      "title": "Automatic complete statistical model building",
      "topics": [
        "buildAll"
      ]
    },
    {
      "page": "buildmlx",
      "title": "Automatic statistical model building",
      "topics": [
        "buildmlx"
      ]
    },
    {
      "page": "buildVar",
      "title": "Automatic model variance building",
      "topics": [
        "buildVar"
      ]
    },
    {
      "page": "confintmlx",
      "title": "Confidence intervals for population parameters",
      "topics": [
        "confintmlx"
      ]
    },
    {
      "page": "covariateSearch",
      "title": "Covariate model building",
      "topics": [
        "covariateSearch"
      ]
    },
    {
      "page": "getEstimatedCovarianceMatrix",
      "title": "Get estimated covariance and correlation matrices",
      "topics": [
        "getEstimatedCovarianceMatrix"
      ]
    },
    {
      "page": "getEstimatedIndividualParameters2",
      "title": "Get estimated individual and population parameters",
      "topics": [
        "getEstimatedIndividualParameters2"
      ]
    },
    {
      "page": "getEstimatedPredictions",
      "title": "Get estimated predictions",
      "topics": [
        "getEstimatedPredictions"
      ]
    },
    {
      "page": "getEstimatedResiduals",
      "title": "Get estimated residuals",
      "topics": [
        "getEstimatedResiduals"
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    },
    {
      "page": "getSimulatedPredictions",
      "title": "Get simulated predictions",
      "topics": [
        "getSimulatedPredictions"
      ]
    },
    {
      "page": "getSimulatedResiduals",
      "title": "Get simulated residuals",
      "topics": [
        "getSimulatedResiduals"
      ]
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    {
      "page": "initRsmlx",
      "title": "Initialize Rsmlx library",
      "topics": [
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      ]
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    {
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      "title": "Automatic PK model building",
      "topics": [
        "pkbuild"
      ]
    },
    {
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      "title": "Compute initial population PK parameters",
      "topics": [
        "pkpopini"
      ]
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      "title": "Read formatted data file",
      "topics": [
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      "title": "Monolix results",
      "topics": [
        "resMonolix"
      ]
    },
    {
      "page": "RsmlxDemo1.project",
      "title": "Monolix project for warfarin PK - 1",
      "topics": [
        "RsmlxDemo1.project"
      ]
    },
    {
      "page": "RsmlxDemo2.project",
      "title": "Monolix project for warfarin PK - 2",
      "topics": [
        "RsmlxDemo2.project"
      ]
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      "page": "setSettings",
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      ]
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      "topics": [
        "testmlx"
      ]
    },
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      "topics": [
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      ]
    },
    {
      "page": "whichPKmodel",
      "title": "Find a Monolix PK model",
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